Protective effect of Shugananlening extract on acute alcohol hepatic injury in mice

XIA Ai-jun; ZHANG Qi; ZHANG Yun-bo; LIANG Yuan; TANG Zhe; ZHOU Ning-ning

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Objective To study the protective effect of Shugananlening extract on acute alcoholic hepatic injury in mice. Methods The model of hepatic injury was prepared by intragastric infusion of alcohol, the change of alanine transaminase (ALT), aspartate transaminase (AST) in serum and liver superoxide dismutase (SOD), malondialdehyde (MDA) and triglyceride (TG) were observed. HE staining was used to observe the pathological changes in liver. Results The level of ALT, AST, TG and MDA were significantly reduced and the activity of SOD was enhanced by different doses of Shugananlening Extract. Furthermore, the pathological injury was also significantly abated by high-dose and middle-dose of Shugananlening Extract. Conclusion Shugananlening extract had a good protective effect on acute alcoholic hepatic injury in mice. The mechanisms probably contributed to the decrease of lipid peroxide and fatty sediment in liver.

Protective effect of Shugananlening extract on acute alcohol hepatic injury in mice

Department of Pharmacy, the 303rd Hospital of PLA, Nanning 530021, China

Received Date: 2011-03-01

Rev Recd Date: 2011-05-25

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Abstract: Objective To study the protective effect of Shugananlening extract on acute alcoholic hepatic injury in mice. Methods The model of hepatic injury was prepared by intragastric infusion of alcohol, the change of alanine transaminase (ALT), aspartate transaminase (AST) in serum and liver superoxide dismutase (SOD), malondialdehyde (MDA) and triglyceride (TG) were observed. HE staining was used to observe the pathological changes in liver. Results The level of ALT, AST, TG and MDA were significantly reduced and the activity of SOD was enhanced by different doses of Shugananlening Extract. Furthermore, the pathological injury was also significantly abated by high-dose and middle-dose of Shugananlening Extract. Conclusion Shugananlening extract had a good protective effect on acute alcoholic hepatic injury in mice. The mechanisms probably contributed to the decrease of lipid peroxide and fatty sediment in liver.

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Protective effect of Shugananlening extract on acute alcohol hepatic injury in mice

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