Analysis of crystal differences of azithromycin precipitated in ethanol-water mixed solvents

JIANG De-hua; LIN Jing-ming; CHEN Jian-ming; WANG Xiao-yan; LI Yuan-yuan; ZHOU Chang-jiang

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Objective To study the crystal differences of azithromycin precipitated in ethanol-water mixed solvents. Methods By differential thermal analysis (DTA), X-ray powder diffraction and C-NMR analysis, the polymorphism of azithromycin were discussed by change the conditions of precipitation to precipitate crystal in ethanol-water mixed solvents. Results 4 kinds of azithromycin isample which had different DTA and XRD characteristics were acquired. Conclusions The DTA and X-ray diffraction characters of azithromycin were obtained, and conditions such as temperature and pressure could expand the research thinking of crystallization.

Analysis of crystal differences of azithromycin precipitated in ethanol-water mixed solvents

1. Graduates Management Brigade, Second Military Medical University, Shanghai 200433, China

2. School of Pharmacy , Second Military Medical University, Shanghai 200433, China

Received Date: 2011-03-01

Rev Recd Date: 2011-05-24

Key words:

azithromycin /
polymorphism /
DTA /
XRD

Abstract: Objective To study the crystal differences of azithromycin precipitated in ethanol-water mixed solvents. Methods By differential thermal analysis (DTA), X-ray powder diffraction and C-NMR analysis, the polymorphism of azithromycin were discussed by change the conditions of precipitation to precipitate crystal in ethanol-water mixed solvents. Results 4 kinds of azithromycin isample which had different DTA and XRD characteristics were acquired. Conclusions The DTA and X-ray diffraction characters of azithromycin were obtained, and conditions such as temperature and pressure could expand the research thinking of crystallization.

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Reference (7)

[1]	王英杰,李玉琴.阿奇霉素的一般药理研究[J].山东医药工业,2000,19(1):76.
[2]	Ghobad M, Hadi V, Mohammad BJ, et al. Development of azithromycin-PLGA nanoparticles: Physicochemical characterization and antibacterial effect against Salmonella typhi[J].Colloid Surface B,2010,80:34.
[3]	Gandhi R, Pillai O, Thilagavathi R, et al. Characterization of Azithromycin hydrates[J]. Eur J Pharm Sci, 2002,16:175.
[4]	Blanco M, Valdés D, Bayod MS, et al. Characterization and analysis of polymorphs by near-infrared spectrometry[J].Anal Chim Acta,2004,502:221.
[5]	Zhang Z, Zhu YH, Yang XL, et al. Preparation of azithromycin microcapsules by a layer-by-layer self-assembly approach and release behaviors of azithromycin[J]. Colloid Surface A,2010,362:135 .
[6]	辉瑞产品公司.阿奇霉素的晶型[P].中国专利. CN1780847A,2006-05-31.
[7]	韩国药品株式会社.阿奇霉素水合物与1,2-丙二醇的包合物,其制备方法及包含其的药物组合物[P].中国专利. CN1505629A,2004-06-16.

[1]	王英杰,李玉琴.阿奇霉素的一般药理研究[J].山东医药工业,2000,19(1):76.
[2]	Ghobad M, Hadi V, Mohammad BJ, et al. Development of azithromycin-PLGA nanoparticles: Physicochemical characterization and antibacterial effect against Salmonella typhi[J].Colloid Surface B,2010,80:34.
[3]	Gandhi R, Pillai O, Thilagavathi R, et al. Characterization of Azithromycin hydrates[J]. Eur J Pharm Sci, 2002,16:175.
[4]	Blanco M, Valdés D, Bayod MS, et al. Characterization and analysis of polymorphs by near-infrared spectrometry[J].Anal Chim Acta,2004,502:221.
[5]	Zhang Z, Zhu YH, Yang XL, et al. Preparation of azithromycin microcapsules by a layer-by-layer self-assembly approach and release behaviors of azithromycin[J]. Colloid Surface A,2010,362:135 .
[6]	辉瑞产品公司.阿奇霉素的晶型[P].中国专利. CN1780847A,2006-05-31.
[7]	韩国药品株式会社.阿奇霉素水合物与1,2-丙二醇的包合物,其制备方法及包含其的药物组合物[P].中国专利. CN1505629A,2004-06-16.

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Analysis of crystal differences of azithromycin precipitated in ethanol-water mixed solvents

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