Experimental study on the antidepressant activities of Isoquercitrin

ZHANG Li-bin; ZHANG Xiao-qing; LI Yu-ping

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Objective To study the antidepressant activities of Isoquercitrin on desperate rats model. Methods ICR Mice were randomly divided into control group,fluoxetine hydrochloride group , Isoquercitrin and Isoquercitrin mixture of different dose groups.The Frost Swimming Test (FST) and the Tail Suspension Test (TST) in mice were applied to evaluate antidepressant activitie. Results Compared with the control group, low dosages(0.3 mg/kg, 3mg/kg) of Isoquercitrin and 10% Isoquercitrin mixture had significantly reduced the immobility time in the behavior tests(P<0.01). Conclusions Low dosage of Isoquercitrin showed some antidepressant activities, which was related to antioxidative effect and inhibiting of adrenocortical hormones.

Experimental study on the antidepressant activities of Isoquercitrin

1. Department of Pharmacy , ShangHai pulmonary Hospital, Tongji University , Shanghai 200433 ,China

2. Department of Pharmacy , ShangHai pulmonary Hospital, Tongji University , Shanghai 200433 ,China;Department of Pharmacy ,The first Pepole's Hospital, Shanghai Jiaotong University ,Shanghai 200080,China

Received Date: 2010-07-21

Rev Recd Date: 2010-12-21

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Abstract: Objective To study the antidepressant activities of Isoquercitrin on desperate rats model. Methods ICR Mice were randomly divided into control group,fluoxetine hydrochloride group , Isoquercitrin and Isoquercitrin mixture of different dose groups.The Frost Swimming Test (FST) and the Tail Suspension Test (TST) in mice were applied to evaluate antidepressant activitie. Results Compared with the control group, low dosages(0.3 mg/kg, 3mg/kg) of Isoquercitrin and 10% Isoquercitrin mixture had significantly reduced the immobility time in the behavior tests(P<0.01). Conclusions Low dosage of Isoquercitrin showed some antidepressant activities, which was related to antioxidative effect and inhibiting of adrenocortical hormones.

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Experimental study on the antidepressant activities of Isoquercitrin

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