Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 27 Issue 1
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2009  >  27(1): 31-32,45

LIU Jia, LI Ke, SUN Hai-ling, FENG Ji-lu. Improvement of synthetic process of tenofovir[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(1): 31-32,45.
Citation: LIU Jia, LI Ke, SUN Hai-ling, FENG Ji-lu. Improvement of synthetic process of tenofovir[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(1): 31-32,45.
shu

Improvement of synthetic process of tenofovir

  • Department of Medicinal Chemistry, School of pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2008-09-25
  • Objective : To improve the synthetic process of tenofovir. Methods : P-toluenesulfonic acid diethoxyphosphorylmethyl ester(4) was prepared from diethyl phosphate and paraformaldehyde by condensation and esterification.9-(2-hydroxy-propyl)adenine(7) was synthesized by reaction of adenine and propylene carbonate.In presence of(CH3)3CONa,compound(7) was connected with compound(4),and then hydrolyzed to tenofovir. Results :The technique was successfully improved due to its low cost,easier operation and less pollution to the environment. Conclusion : The overall yield of the improved synthetic process was 30%,which is more suitable for industrial production.
  • 加载中
通讯作者: 陈斌, [email protected]
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2648) PDF downloads(1733) Cited by()

Related
Proportional views

Improvement of synthetic process of tenofovir

  • Department of Medicinal Chemistry, School of pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2008-09-25

Abstract: Objective : To improve the synthetic process of tenofovir. Methods : P-toluenesulfonic acid diethoxyphosphorylmethyl ester(4) was prepared from diethyl phosphate and paraformaldehyde by condensation and esterification.9-(2-hydroxy-propyl)adenine(7) was synthesized by reaction of adenine and propylene carbonate.In presence of(CH3)3CONa,compound(7) was connected with compound(4),and then hydrolyzed to tenofovir. Results :The technique was successfully improved due to its low cost,easier operation and less pollution to the environment. Conclusion : The overall yield of the improved synthetic process was 30%,which is more suitable for industrial production.

LIU Jia, LI Ke, SUN Hai-ling, FENG Ji-lu. Improvement of synthetic process of tenofovir[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(1): 31-32,45.
Citation: LIU Jia, LI Ke, SUN Hai-ling, FENG Ji-lu. Improvement of synthetic process of tenofovir[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(1): 31-32,45.
shu

    HTML

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: [email protected]

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return