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QIN Cuiying, LI Rongli, LI Yunjing, CHEN Rencai, HAN Jing. Optimization of the preparation process for echinacoside in Herba Cistanche enteric microspheres by response surface methodology[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(5): 411-414,432. doi: 10.3969/j.issn.1006-0111.2017.05.006
Citation:
QIN Cuiying, LI Rongli, LI Yunjing, CHEN Rencai, HAN Jing. Optimization of the preparation process for echinacoside in Herba Cistanche enteric microspheres by response surface methodology[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(5): 411-414,432. doi: 10.3969/j.issn.1006-0111.2017.05.006
Optimization of the preparation process for echinacoside in Herba Cistanche enteric microspheres by response surface methodology
Shenyang Pharmaceutical University, Shenyang 110016, China
Received Date: 2016-11-25
Rev Recd Date:
2017-04-25
Abstract
Objective To prepare Herba Cistanche enteric release microspheres, optimize the preparation process and study the releasing characteristics of microspheres in vitro. Methods Ion gelatin-oven drying method was used to prepare Herba Cistanche enteric microspheres. The preparation process was optimized with the aid of a Box-Behnken design. Results The optimal preparation condition was 36.33 mg/ml of sodium alginate, 10.82 mg/ml of calcium chloride and 10.93 mg/ml of chitosan. Conclusion This technology is repeatable and feasible. The microspheres have high entrapment efficiency and good sustained release characteristics.
Yang F, Wen D, Fang B, et al. Prevention of Cistanche salsa extract on hepatic fibrosis induced by carbon tetrachloride in rats［J］.CHM, 2013, 5(3): 199-204.
[3]
Zhang D, Li H, Wang JB. Echinacoside inhibits amyloid fibrillization of HEWL and protects against Aβ-induced neurotoxicity［J］. Int J Biol Maromol, 2015, 72: 243-253.
Li F, Yang X, Yang Y, et al. Phospholipid complex as an approach for bioavailability enhancement of echinacoside［J］. Drug Dev Ind Pharm, 2015, 41(11): 1777-1784.
Li M, Li Y, Liu W, et al. The preparation of Cistanche phenylethanoid glycosides liquid proliposomes: Optimized formulation, characterization and proliposome dripping pills in vitro and in vivo evaluation［J］. Eur J Pharm Sci, 2016, 93: 224-232.
Abstract: Objective To prepare Herba Cistanche enteric release microspheres, optimize the preparation process and study the releasing characteristics of microspheres in vitro. Methods Ion gelatin-oven drying method was used to prepare Herba Cistanche enteric microspheres. The preparation process was optimized with the aid of a Box-Behnken design. Results The optimal preparation condition was 36.33 mg/ml of sodium alginate, 10.82 mg/ml of calcium chloride and 10.93 mg/ml of chitosan. Conclusion This technology is repeatable and feasible. The microspheres have high entrapment efficiency and good sustained release characteristics.
QIN Cuiying, LI Rongli, LI Yunjing, CHEN Rencai, HAN Jing. Optimization of the preparation process for echinacoside in Herba Cistanche enteric microspheres by response surface methodology[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(5): 411-414,432. doi: 10.3969/j.issn.1006-0111.2017.05.006
Citation:
QIN Cuiying, LI Rongli, LI Yunjing, CHEN Rencai, HAN Jing. Optimization of the preparation process for echinacoside in Herba Cistanche enteric microspheres by response surface methodology[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(5): 411-414,432. doi: 10.3969/j.issn.1006-0111.2017.05.006
Yang F, Wen D, Fang B, et al. Prevention of Cistanche salsa extract on hepatic fibrosis induced by carbon tetrachloride in rats［J］.CHM, 2013, 5(3): 199-204.
[3]
Zhang D, Li H, Wang JB. Echinacoside inhibits amyloid fibrillization of HEWL and protects against Aβ-induced neurotoxicity［J］. Int J Biol Maromol, 2015, 72: 243-253.
Li F, Yang X, Yang Y, et al. Phospholipid complex as an approach for bioavailability enhancement of echinacoside［J］. Drug Dev Ind Pharm, 2015, 41(11): 1777-1784.
Li M, Li Y, Liu W, et al. The preparation of Cistanche phenylethanoid glycosides liquid proliposomes: Optimized formulation, characterization and proliposome dripping pills in vitro and in vivo evaluation［J］. Eur J Pharm Sci, 2016, 93: 224-232.
QIN Cuiying, LI Rongli, LI Yunjing, CHEN Rencai, HAN Jing. Optimization of the preparation process for echinacoside in Herba Cistanche enteric microspheres by response surface methodology[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(5): 411-414,432. doi: 10.3969/j.issn.1006-0111.2017.05.006
QIN Cuiying, LI Rongli, LI Yunjing, CHEN Rencai, HAN Jing. Optimization of the preparation process for echinacoside in Herba Cistanche enteric microspheres by response surface methodology[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(5): 411-414,432. doi: 10.3969/j.issn.1006-0111.2017.05.006
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