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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2016  >  34(1): 72-75

DENG Zhaohui, LI Aihong, HU Wenjun. Improvement of quality control of lidocaine hydrochloride injectio[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 72-75. doi: 10.3969/j.issn.1006-0111.2016.01.019
Citation: DENG Zhaohui, LI Aihong, HU Wenjun. Improvement of quality control of lidocaine hydrochloride injectio[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 72-75. doi: 10.3969/j.issn.1006-0111.2016.01.019
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Improvement of quality control of lidocaine hydrochloride injectio

doi: 10.3969/j.issn.1006-0111.2016.01.019

  • Drug and Instrument Control Instituteof Guangzhou Military Command, Guangzhou 510500, China

  • Received Date: 2015-02-05
  • Rev Recd Date: 2015-06-03
  • Objective To improve the quality control standard of lidocaine hydrochloride injection. Methods A method for determination of related substances in lidocaine hydrochloride injection was established. Lidocaine hydrochloride was assayed by HPLC. The chromatographic conditions: C18 chromatographic column was used. The mobile phase was phosphate buffer and acetonitrile (50:50,adjusted to pH 8 with phosphoric acid). The detection wavelength was 254 nm. Results According to the result of method verification, related substances could be examined by HPLC.Lidocaine hydrochloride was assayed by HPLC, which showed excellent linearity at the range of 373.62-3 736.19 μg/ml. The average recoveries were 102.1%(RSD=0.9%). Conclusion The improved standard could be used to control the quality of lidocaine hydrochloride injection.
  • [1] 总后卫生部.中国人民解放军医疗机构制剂规范[S].北京:人民军医出版社,2002:298-299.
    [2] 国家药典委员会.中华人民共和国药典2010年版二部[S].北京:中国医药科技出版社,2010:709-710.
    [3] 王曙东,潘 璟,方 李,等.反相高效液相色谱法测定壳糖止血海绵中诺氟沙星和盐酸利多卡因的含量[J].药学实践杂志,2010,28(1):45-47.
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Improvement of quality control of lidocaine hydrochloride injectio

doi: 10.3969/j.issn.1006-0111.2016.01.019
  • Drug and Instrument Control Instituteof Guangzhou Military Command, Guangzhou 510500, China
  • Received Date: 2015-02-05
  • Rev Recd Date: 2015-06-03

Abstract: Objective To improve the quality control standard of lidocaine hydrochloride injection. Methods A method for determination of related substances in lidocaine hydrochloride injection was established. Lidocaine hydrochloride was assayed by HPLC. The chromatographic conditions: C18 chromatographic column was used. The mobile phase was phosphate buffer and acetonitrile (50:50,adjusted to pH 8 with phosphoric acid). The detection wavelength was 254 nm. Results According to the result of method verification, related substances could be examined by HPLC.Lidocaine hydrochloride was assayed by HPLC, which showed excellent linearity at the range of 373.62-3 736.19 μg/ml. The average recoveries were 102.1%(RSD=0.9%). Conclusion The improved standard could be used to control the quality of lidocaine hydrochloride injection.

DENG Zhaohui, LI Aihong, HU Wenjun. Improvement of quality control of lidocaine hydrochloride injectio[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 72-75. doi: 10.3969/j.issn.1006-0111.2016.01.019
Citation: DENG Zhaohui, LI Aihong, HU Wenjun. Improvement of quality control of lidocaine hydrochloride injectio[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 72-75. doi: 10.3969/j.issn.1006-0111.2016.01.019
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