Screening the best ratio of artesunate and ursolic acid for lipid-lowering

YE Yalin; WANG Yuliang; WANG Zejian; YIN Ming; XIN Hailiang; ZHANG Lei

doi:10.3969/j.issn.1006-0111.2014.03.008

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Objective To observe the effect of different doses unilateral and compound of artesunate and ursolic acid on lipid metabolism in rats' model, find out the best ratio of artesunate and ursolic acid. Methods Lipid metabolism disorders model was induced by feeding high fat diet in rat.The best ratio was screened through comparing the lipid level of rats ofdifferent groups. Results The results showed that Artesunate (high dose)+Ursolicacid (high dose) significantly reduced TG, CHO and LDL-C, increased HDL-C and H/L. Lipid-lowering effect was superior the positive drug fenofibrate, but also superior to the same dose of artesunate and ursolic acid alone. No significant effect of each test sample on the rat liver function was observed(P>0.05). Conclusion Artesunate and ursolic acid ratio of 1:1 had the best lipid-lowering effect, and the recommended dose was (50+50) mg/kg.

Screening the best ratio of artesunate and ursolic acid for lipid-lowering

1. NO.421 Hospital of PLA, Guangzhou 510310, China

2. School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China;School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China

3. School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China

4. School of Traditional;Chinese Medicine, Second Military Medical University, Shanghai 200433, China

5. School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2013-05-01

Rev Recd Date: 2013-09-12

Key words:

Abstract: Objective To observe the effect of different doses unilateral and compound of artesunate and ursolic acid on lipid metabolism in rats' model, find out the best ratio of artesunate and ursolic acid. Methods Lipid metabolism disorders model was induced by feeding high fat diet in rat.The best ratio was screened through comparing the lipid level of rats ofdifferent groups. Results The results showed that Artesunate (high dose)+Ursolicacid (high dose) significantly reduced TG, CHO and LDL-C, increased HDL-C and H/L. Lipid-lowering effect was superior the positive drug fenofibrate, but also superior to the same dose of artesunate and ursolic acid alone. No significant effect of each test sample on the rat liver function was observed(P>0.05). Conclusion Artesunate and ursolic acid ratio of 1:1 had the best lipid-lowering effect, and the recommended dose was (50+50) mg/kg.

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Reference (12)

[1]	Xu H, He Y, Yang X, et al. Anti-malarial agent artesunate inhibits TNF-alpha-induced production of proinflammatory cytokines via inhibition of NF-kappaB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes[J]. Rheumatology,2007,46 (6):920-926.
[2]	Wang JX, Tang W, Zhou R, et al.The new water-soluble artemisinin derivative SM905 ameliorates collagen-induced arthritis by suppression of inflammatory and Th17 responses[J]. Br J Pharmacol, 2008, 153(6): 1303-1310.
[3]	Li WD, Dong YJ, Tu YY, et al.Dihydroarteannuin ameliorates lupus symptom of BXSB mice by inhibiting production of TNF-alpha and blocking the signaling pathway NF-kappa B translocation[J]. Int Immunopharmacol,2006,6 (8): 1243-1250.
[4]	Li B, Zhang R, Li J, et al. Antimalarial artesunate protects sepsis model mice against heat-killed Escherichia coli challenge by decreasing TLR4, TLR9 mRNA expressions and transcription factor NF-kappa B activation[J]. Int Immunopharmacol, 2008, 8(3): 379-389.
[5]	Li T,Chen H,Wei N,et al. Anti-inflammatory and immunomodulatory mechanisms of artemisinin on contact hypersensitivity[J]. Int Immunopharmacol, 2012, 12(1):144-150.
[6]	Hou LF, He SJ, Li X, et al. Oral administration of artemisinin analog SM934 ameliorates lupus syndromes in MRL/lpr mice by inhibiting Th1 and Th17 cell responses[J]. Arthritis Rheum, 2011, 63(8): 2445-2455.
[7]	Cheng C, Ho WE, Goh FY, et al. Anti-malarial drug artesunate attenuates experimental allergic asthma via inhibition of the phosphoinositide 3-kinase/Akt pathway[J]. PLoS One, 2011, 6(6): e20932.
[8]	Li Y, Wu YL. An over four millennium story behind qinghaosu (artemisinin)-a fantastic antimalarial drug from a traditional Chinese herb[J]. Curr Med Chem, 2003, 10 (21):2197-2223.
[9]	Jayaprakasam B, Olson LK, Schutzki RE, et al. Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas)[J]. J Agric Food Chem,2006,54(1):243-248.
[10]	Somova LO, Nadar A, Rammanan P, et al. Cardiovascular, antihyperlipidemic and antioxidant effects of oleanolic and ursolic acids in experimental hypertension[J]. Phytomedicine,2003,10(2-3), 115-121.
[11]	Ullevig SL, Zhao Q, Zamora D, et al. Ursolic acid protects diabetic mice against monocyte dysfunction and accelerated atherosclerosis[J]. Atherosclerosis,2011,219 (2), 409-416.
[12]	唐克轩,王玉亮,辛海量.降血脂的中药组合物及其制备方法[P]. 中国专利,CN101507727,2009-08-19.

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Screening the best ratio of artesunate and ursolic acid for lipid-lowering

doi: 10.3969/j.issn.1006-0111.2014.03.008

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