真菌<i>Chaetomium</i> sp.的次级代谢产物研究

孟慧; 许勇

doi:10.3969/j.issn.1006-0111.2019.04.006

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

x 关闭永久关闭

应中央军委要求，2022年9月起，《药学实践杂志》将更名为《药学实践与服务》，双月刊，正文96页；2023年1月起，拟出版月刊，正文64页，数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿！

真菌Chaetomium sp.的次级代谢产物研究

孟慧, 许勇

文章导航 > 药学实践与服务 > 2019 > 37(4): 314-317

孟慧, 许勇. 真菌Chaetomium sp.的次级代谢产物研究[J]. 药学实践与服务, 2019, 37(4): 314-317. doi: 10.3969/j.issn.1006-0111.2019.04.006

引用本文:

孟慧, 许勇. 真菌Chaetomium sp.的次级代谢产物研究[J]. 药学实践与服务, 2019, 37(4): 314-317. doi: 10.3969/j.issn.1006-0111.2019.04.006

MENG Hui, XU Yong. Study on the secondary metabolites of the fungus Chaetomium sp.[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(4): 314-317. doi: 10.3969/j.issn.1006-0111.2019.04.006

Citation:

MENG Hui, XU Yong. Study on the secondary metabolites of the fungus Chaetomium sp.[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(4): 314-317. doi: 10.3969/j.issn.1006-0111.2019.04.006

真菌Chaetomium sp.的次级代谢产物研究

doi: 10.3969/j.issn.1006-0111.2019.04.006

孟慧,
许勇

中国人民解放军海军905医院设备科, 上海, 200052

基金项目: 国家自然科学基金（81573342）

Study on the secondary metabolites of the fungus Chaetomium sp.

MENG Hui,
XU Yong

Hospital 905 of PLA Navy, Shanghai 200052, China

摘要: 目的对海洋毛壳属真菌Chaetomium sp.的次级代谢产物进行研究。方法运用硅胶柱色谱、Sephadex LH-20凝胶柱色谱、HPLC等现代色谱方法对Chaetomium sp.的发酵产物进行分离纯化，利用现代波谱技术结合文献报道进行结构鉴定。结果共分离得到4个十元环内酯化合物，botryolides A、botryolides B、botryolides D和decarestrictine I，1个倍半萜类化合物trichothecolone。结论本研究是对海洋真菌Chaetomium sp.次级代谢产物的首次报道，5种化合物均为首次从该种真菌中分离得到。
- 海洋真菌 /
- 毛壳属 /
- 十元环内酯 /
- 倍半萜 /
- 细胞毒活性
Abstract: Objective To investigate the secondary metabolites of the marine fungi Chaetomium sp. Methods The EtOAc extract of Chaetomium sp.fermentation was purified by repeated column chromatography on silica gel,Sephadex LH-20,and high-performance liquid chromatography.The isolated compounds were structurally elucidated by spectroscopic analysis and by comparison with literatures previously reported. Results Four nonanolides including botryolides A,B,D,decarestrictine I,together with one sesquiterpene trichothecolone were isolated and structurally elucidated. Conclusion 5 Compounds were reported for the first time from the marine fungi Chaetomium sp.
- marine fungi /
- Chaetomium sp. /
- nonanolide /
- sesquiterpene /
- cytotoxicity

[1]	NEWMAN D J,CRAGG G M,SNADER K M.The influence of natural products upon drug discovery[J].Nat Prod Rep,2000,17(3):215-234.
[2]	JENSEN P R,MOORE B S,FENICAL W.The marine actinomycete genus Salinispora:a model organism for secondary metabolite discovery[J].Nat Prod Rep,2015,32(5):738-751.
[3]	FENICAL W,JENSEN P R.Developing a new resource for drug discovery:marine actinomycete bacteria[J].Nat Chem Biol,2006,2(12):666-673.
[4]	HOU X M,XU R F,GU Y C,et al.Biological and chemical diversity of coral-derived microorganisms[J].Curr Med Chem,2015,22(32):3707-3762.
[5]	ZHAO C Y,ZHU H T,ZHU W M.New marine natural products of microbial origin from 2010 to 2013[J].Chin J Org Chem (有机化学),2013,33(6):1195-1234.
[6]	KIRK P M,CANNON P F,DAVID J C,et al.Ainsworth and Bisby's dictionary of the fungi,9th Edition,[M].CABI Publishing,2001.
[7]	FATIMA N,MUKHTAR U,IHSAN UL H,et al.Biologicalevaluation of endophytic fungus Chaetomium sp.NF15 of Justicia adhatoda L.:A potential candidate for drug discovery[J].Jundishapur J Microbiol,2016,9(6):e29978.
[8]	JIAO R H,XU S,LIU J Y,et al.Chaetominine,a cytotoxic alkaloid produced by endophytic Chaetomium sp.IFB-E015[J].Org Lett,2006,8(25):5709-5712.
[9]	SY A A,SWENSON D C,GLOER J B,et al.Botryolides A-E,decarestrictine analogues from a fungicolous Botryotrichum sp.(NRRL 38180)[J].J Nat Prod,2008,71(3):415-419.
[10]	RADHA KRISHNA P,RAO T J.Total synthesis of decarestrictine I and botryolide B via RCM protocol[J].Org Biomol Chem,2010,8(14):3130-3132.
[11]	LOUKACI A,KAYSER O,BINDSEIL K,et al.New trichothecenes isolated from Holarrhena floribunda[J].J Nat Prod,2000,63(1):52-56.
[12]	SUN P,LU S,REE T,et al.Nonanolides ofnatural origin:structure,synthesis,and biological activity[J].Curr Med Chem,2012,19:3417-3455.
[13]	YADAV J S,VENKATESH M,KUMAR A S,et al.Astereoselective total synthesis of decarestrictine I[J].Helv Chim Acta,2014,97(6):830-838.
[14]	PHILIPPS S,MAYER M,G HRT A,et al.[P],EP,0497300A12,1992.
[15]	WU Q,DOHNAL V,KUCA K,et al.Trichothecenes:structure-toxic activity relationships[J],Curr Drug Metab,2013,14(6):641-660.

[1]	刘丽艳, 余小翠, 孙传铎. 纳武利尤单抗治疗非小细胞肺癌有效性及安全性的Meta分析 . 药学实践与服务, 2024, 42(10): 451-456. doi: 10.12206/j.issn.2097-2024.202310044
[2]	迟文雅, 袁艳, 李伟林, 吴茼妤, 俞媛. 负载骨髓间充质干细胞/白藜芦醇脂质体的水凝胶支架用于创伤性脑损伤治疗 . 药学实践与服务, 2024, 42(): 1-8. doi: 10.12206/j.issn.2097-2024.202406034
[3]	宋雨桐, 夏德润, 顾珩, 唐少文, 易洪刚, 沃红梅. 帕博利珠单抗与铂类化疗方案在晚期非小细胞肺癌一线治疗中的药物经济学评价 . 药学实践与服务, 2024, 42(8): 334-340. doi: 10.12206/j.issn.2097-2024.202303023
[4]	冯志惠, 邓仪卿, 叶冰, 安培, 张宏, 张海军. 雀梅藤石油醚提取物诱导三阴性乳腺癌细胞凋亡的实验研究 . 药学实践与服务, 2024, 42(6): 253-259. doi: 10.12206/j.issn.2097-2024.202311055
[5]	修建平, 杨朝爱, 刘禧澳, 潘乾禹, 韦广旭, 王卫星. 全反式维甲酸对肝星状细胞活化及氧化应激的作用和机制探索 . 药学实践与服务, 2024, 42(7): 291-296. doi: 10.12206/j.issn.2097-2024.202312054
[6]	姜涛, 徐卫凡, 蒋益萍, 夏天爽, 辛海量. 巴戟天丸组方对Aβ损伤成骨细胞的作用及基于网络药理学的机制研究 . 药学实践与服务, 2024, 42(7): 285-290, 296. doi: 10.12206/j.issn.2097-2024.202305011
[7]	杨媛媛, 安晓强, 许佳捷, 江键, 梁媛媛. 正极性驻极体联合5-氟尿嘧啶对瘢痕成纤维细胞生长抑制的协同作用 . 药学实践与服务, 2024, 42(6): 244-247. doi: 10.12206/j.issn.2097-2024.202310027
[8]	陈静, 何瑞华, 翁月, 徐熠, 刘静, 黄瑾. 基于网络药理学和分子对接技术探究定清片活性成分治疗白血病的作用机制 . 药学实践与服务, 2024, 42(11): 479-486. doi: 10.12206/j.issn.2097-2024.202401073
[9]	赖立勇, 夏天爽, 徐圣焱, 蒋益萍, 岳小强, 辛海量. 中药青蒿抗氧化活性的谱效关系研究 . 药学实践与服务, 2024, 42(5): 203-210, 216. doi: 10.12206/j.issn.2097-2024.202211012

点击查看大图

计量

文章访问数: 3948
HTML全文浏览量: 414
PDF下载量: 438
被引次数: 0

真菌Chaetomium sp.的次级代谢产物研究

doi: 10.3969/j.issn.1006-0111.2019.04.006

孟慧,
许勇

中国人民解放军海军905医院设备科, 上海, 200052

基金项目: 国家自然科学基金（81573342）

收稿日期: 2018-11-06
修回日期: 2019-02-25

关键词:

海洋真菌 /

毛壳属 /

十元环内酯 /

倍半萜 /

细胞毒活性

摘要: 目的对海洋毛壳属真菌Chaetomium sp.的次级代谢产物进行研究。方法运用硅胶柱色谱、Sephadex LH-20凝胶柱色谱、HPLC等现代色谱方法对Chaetomium sp.的发酵产物进行分离纯化，利用现代波谱技术结合文献报道进行结构鉴定。结果共分离得到4个十元环内酯化合物，botryolides A、botryolides B、botryolides D和decarestrictine I，1个倍半萜类化合物trichothecolone。结论本研究是对海洋真菌Chaetomium sp.次级代谢产物的首次报道，5种化合物均为首次从该种真菌中分离得到。

English Abstract

孟慧, 许勇. 真菌Chaetomium sp.的次级代谢产物研究[J]. 药学实践与服务, 2019, 37(4): 314-317. doi: 10.3969/j.issn.1006-0111.2019.04.006

引用本文:

孟慧, 许勇. 真菌Chaetomium sp.的次级代谢产物研究[J]. 药学实践与服务, 2019, 37(4): 314-317. doi: 10.3969/j.issn.1006-0111.2019.04.006

MENG Hui, XU Yong. Study on the secondary metabolites of the fungus Chaetomium sp.[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(4): 314-317. doi: 10.3969/j.issn.1006-0111.2019.04.006

Citation: