依布硒的生理活性及合成方法研究进展

刘晓盈; 孙一鸣; 赵宇亭; 吴显东; 马鹏程; 杨超; 郑灿辉

doi:10.3969/j.issn.1006-0111.2017.01.002

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依布硒的生理活性及合成方法研究进展

刘晓盈, 孙一鸣, 赵宇亭, 吴显东, 马鹏程, 杨超, 郑灿辉

文章导航 > 药学实践与服务 > 2017 > 35(1): 5

刘晓盈, 孙一鸣, 赵宇亭, 吴显东, 马鹏程, 杨超, 郑灿辉. 依布硒的生理活性及合成方法研究进展[J]. 药学实践与服务, 2017, 35(1): 5. doi: 10.3969/j.issn.1006-0111.2017.01.002

引用本文:

LIU Xiaoying, SUN Yiming, ZHAO Yuting, WU Xiandong, MA Pengchengb, YANG Chaoa, ZHENG Canhuia. Progress on physiological activities and synthetic methods of ebselen[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(1): 5. doi: 10.3969/j.issn.1006-0111.2017.01.002

Citation:

LIU Xiaoying, SUN Yiming, ZHAO Yuting, WU Xiandong, MA Pengchengb, YANG Chaoa, ZHENG Canhuia. Progress on physiological activities and synthetic methods of ebselen[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(1): 5. doi: 10.3969/j.issn.1006-0111.2017.01.002

依布硒的生理活性及合成方法研究进展

doi: 10.3969/j.issn.1006-0111.2017.01.002

1.
第二军医大学药学院, 上海 200433
2.
第二军医大学学员旅, 上海 200433

基金项目: 第二军医大学大学生创新能力培养基金（MS2014059）资助

Progress on physiological activities and synthetic methods of ebselen

1.
School of Pharmacy, Second Military Medical University, Shanghai 200433, China
2.
Cadet Brigade, Second Military Medical University, Shanghai 200433, China

摘要: 有机硒类化合物是一类具有广泛生理活性的生物活性物质。依布硒是其代表化合物，它作为谷胱甘肽过氧化物酶的小分子模拟物可以被用于心脑血管疾病、炎症和噪声致听力损伤等多种疾病的治疗。笔者简要综述了依布硒的生理活性和合成方法的研究进展。
- 依布硒 /
- 有机硒类化合物 /
- 谷胱甘肽过氧化物酶 /
- 生理活性 /
- 合成方法
Abstract: Organoselenium compounds are bioactive substances with extensive physiological activities. As a representative compound, ebselen could be used as mimics of glutathione peroxidase, and in the treatment of many diseases, such as cardiovascular and cerebrovascular diseases, inflammation and noise-induced hearing loss. the research progress in physiological activities and synthetic methods of ebselen were reviewed in this paper.
- ebselen /
- organoselenium compounds /
- glutathione peroxidase /
- physiological activities /
- synthetic methods

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