核苷酸适体在靶向给药系统中的应用进展

熊叶; 台宗光; 李强

doi:10.3969/j.issn.1006-0111.2015.06.003

核苷酸适体在靶向给药系统中的应用进展

doi: 10.3969/j.issn.1006-0111.2015.06.003

1.
第二军医大学附属长海医院, 上海 200433
2.
第二军医大学附属长海医院, 上海 200433;解放军92330部队医院, 山东青岛 266102

基金项目: 国家自然科学基金项目(No.81170060)

Application progress of nucleic acid aptamers in targeted drug delivery system

1.
Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China
2.
Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China;Hospital of CPLA No.92330 Troop, Qingdao 266102, China

摘要: 适体,即体外合成筛选得到的能特异性地与靶分子结合的一段寡核苷酸序列。由于其独特的性质,在靶向给药系统中有着广阔的应用前景,目前已成为靶向给药研究领域的热点。综述了适体在靶向给药系统中的优势及其应用进展,并对其应用前景和面临的问题进行分析。
- 核苷酸适体 /
- 靶向给药 /
- 应用进展
Abstract: Aptamers are single stranded oligonucleotides that have high affinity and specificity towards a wide range of target molecules. Owing to the indispensable advantages, aptamers have wildly prospects and have become a research hotspot in targeted drug delivery system (TDDS). In this article, application advantage and progress of aptamers in TDDS were briefly reviewed, the problems and prospects were also discussed.
- nucleic acid aptamers /
- targeted drug delivery /
- application progress

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核苷酸适体在靶向给药系统中的应用进展

doi: 10.3969/j.issn.1006-0111.2015.06.003

Application progress of nucleic acid aptamers in targeted drug delivery system

计量

核苷酸适体在靶向给药系统中的应用进展

doi: 10.3969/j.issn.1006-0111.2015.06.003

1. 第二军医大学附属长海医院, 上海 200433

2. 第二军医大学附属长海医院, 上海 200433;解放军92330部队医院, 山东青岛 266102

English Abstract

Application progress of nucleic acid aptamers in targeted drug delivery system

1. Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China

2. Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China;Hospital of CPLA No.92330 Troop, Qingdao 266102, China

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留言板

核苷酸适体在靶向给药系统中的应用进展

doi: 10.3969/j.issn.1006-0111.2015.06.003

Application progress of nucleic acid aptamers in targeted drug delivery system

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出版历程

核苷酸适体在靶向给药系统中的应用进展

doi: 10.3969/j.issn.1006-0111.2015.06.003

1. 第二军医大学附属长海医院, 上海 200433 2. 第二军医大学附属长海医院, 上海 200433;解放军92330部队医院, 山东 青岛 266102

English Abstract

Application progress of nucleic acid aptamers in targeted drug delivery system

1. Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China 2. Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China;Hospital of CPLA No.92330 Troop, Qingdao 266102, China

全文HTML

目录

1. 第二军医大学附属长海医院, 上海 200433

2. 第二军医大学附属长海医院, 上海 200433;解放军92330部队医院, 山东青岛 266102

1. Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China

2. Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China;Hospital of CPLA No.92330 Troop, Qingdao 266102, China