中药复方药动学研究方法概述

彭成成; 金慧子; 柳润辉

doi:10.3969/j.issn.1006-0111.2015.01.002

中药复方药动学研究方法概述

doi: 10.3969/j.issn.1006-0111.2015.01.002

1.
上海交通大学药学院, 上海 200240
2.
第二军医大学药学院天然药物化学教研室, 上海 200433

Summary of the pharmacokinetic methods of traditional Chinese medicine prescription

1.
School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China
2.
Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

摘要: 概述中药复方药动学研究的几种方法,包括生物效应法、血药浓度法、中药复方多效应成分整合药动学及中药复方药动学-药效学结合模型,阐明各自的特征及优缺点,并对中药复方药动学研究方法的发展进行总结和展望。
- 中药复方 /
- 药动学 /
- 研究方法
Abstract: This review made a brief summary of several pharmacokinetic methods of traditional Chinese medicine (TCM) prescription including the methods of biological effects,plasma concentration,integrated Pharmacokinetics of multiple effective components of TCM prescription and integrated pharmacokinetic-pharmacodynamic of TCM prescription.The corresponding characteristics,advantages and disadvantages of each of these methods were analyzed.And the progresses of the pharmacokinetic methods of TCM prescription were concluded and prospected.
- traditional Chinese medicine (TCM) prescription /
- pharmacokinetics /
- research methods

[1]	郝福,蒋晔,李艳荣,等.复方中药化学成分的研究进展[J].中成药,2007,29(2):258-262.
[2]	梁文权.生物药剂学与药物动力学[M].3版.北京:人民卫生出版社,2007:169-171.
[3]	Smolen VF,Barile RG,Theophanous TG.Relationship between dose,effect,time and biophasic drug levels[J].J Pharm Sci,1972,61 (3):467-470.
[4]	肇丽梅,何晓静,邱枫.药理效应法测定黄芩苷及清热合剂的药动学参数[J].广东药学院学报,2006,22(1):22-24.
[5]	赫梅生,詹丽芬,郭景阳,等.用动物急性死亡率估计药物体存率与表观半衰期[J].中国药理学报,1985,6(3):213-216.
[6]	马昕.浅谈中药复方的药代动力学[J].北方药学,2011,8(11):18-19.
[7]	刘萍,黄颖.中药复方的药代动力学研究方法和存在的若干问题[J].湖北中医学院学报,2010,12(6):64-66.
[8]	黄衍民,潘留华,吴晓放,等.乌头注射液对小鼠的毒效动力学研究[J].中国药学,1998,33(7):421-423.
[9]	周丽娟,许利平,陈慧娟,等,中药复方药代动力学常用研究方法评价[J].中华中医药学刊,2007,25(5):1041-1043.
[10]	向大雄,李焕德,胥新元.中药复方药代动力学研究概况[J].中国实验方剂学杂志,2002,8(1):61-63.
[11]	Wei H,Xu W,Cai F,et al.Simultaneous determination of five lignin constituents of Wuzhi capsule in rat plasma by LC-MS/MS:application to pharmacokinetic study[J].J Pharm Biomed Anal,2010,52 (5):741-746.
[12]	Liu P,Li ZH,Qian DW,et al.Simultaneous determination of bioactive components in essential oil of Xiang-Fu-Si-Wu formula in Beagle dog plasma by UPLC-MS/MS and its application to pharmacokinetics[J].J Chromatogr B,2013,929:63-69.
[13]	Cai F,Xu W,Wei H,et al.Simultaneous determination of active xanthone glycosides,timosaponins and alkaloids in rat plasma after oral administration of Zi-Shen Pill extract for the pharmacokinetic study by liquid chromatography-tandem mass spectrometry[J].J Chromatogr B,2010,878 (21):1845-1854.
[14]	Zuo F,Zhou ZM,Zhang Q,et al.Pharmacokinetic study on the multi-constituents of Huang Qin-Tang decoction in rats[J].Biol Pharm Bull,2003,26 (7):911-919.
[15]	谢跃生,张振清,阮金秀.六味地黄汤中马钱子素小鼠体内药代动力学研究[J].中草药,2002,33(9):817-819.
[16]	汤成泳,李卿,周远大,等.麝香滴眼液在家兔眼内组织中的分布及药代动力学研究[J].中成药,2010,32(4):581-585.
[17]	贺丰,罗佳波,陈飞龙,等.GC-MS法研究麻黄汤中麻黄碱、伪麻黄碱的人体内过程[J].中药新药与临床药理,2004,15(5):336-347.
[18]	Lu T,Liang Y,Song J,et al.Simultaneous determination of berberine and palmatine in rat plasma by HPLC-ESI-MS after oral administration of traditional Chinese medicinal preparation Huang-Lian-Jie-Du decoction and the pharmacokinetic application of the method[J].J Pharm Biomed Anal,2006,40 (5) :1218-1224.
[19]	Xia CH,Wang GJ,Sun JG,et al.Simultaneous determination of ginsenoside Rg1,Re,Rd,Rb1 and ophiopogonin D in rat plasma by liquid chromatography/electrosprayionization mass spectrometric method and its applicationto pharmacokinetic study of SHENMAI' injection[J].J Chromatogr B,2008,862 (1-2):72-78.
[20]	Zan B,Shi R,Wang TM,et al.Simultaneous quantification of multiple active components from Xiexin decoction in rat plasma by LC-ESI-MS/MS:application in pharmacokinetics[J].Biomed Chromatogr,2011,25 (7):816-826.
[21]	吕莉,孙慧君,韩国柱.中药药代动力学的研究进展[J].药学学报,2013,48(3):824-833.
[22]	张启云,徐良辉,李冰涛,等.复方葛根芩连汤多效应成分分类整合药代动力学研究[J].中国临床药理学与治疗学,2011,16(1):51-56.
[23]	Zhu HX,Qian ZL,Li H,et al.Integrated pharmacokinetics of major bioactive components in MCAO rats after oral administration of Huang-Lian-Jie-Du-Tang[J].J Ethnopharmacol,2012,141 (1):158-169.
[24]	李锐,晏亦林,周莉玲,等.四逆汤的药动学研究[J].中成药,2002,24(10):777-780.
[25]	田乐,狄留庆,周伟,等.中药多组分网络靶点效应PK-PD结合模型应用研究与思考[J].世界科学技术:中医药现代化,2012,14(4):1824-1830.
[26]	向铮,蔡小军,曾苏.基于复杂网络与代谢组学的中药药代动力学研究思考与探索[J].药学学报,2012,47(5):558-564.

[1]	王耀振, 徐灿, 吕顺莉, 田泾, 张东炜. 钾离子竞争性酸阻滞剂的药学特征研究进展 . 药学实践与服务, 2024, 42(7): 278-284. doi: 10.12206/j.issn.2097-2024.202306040
[2]	毛泽玲, 文波. 大黄的HPLC指纹图谱及禁用农药的残留研究 . 药学实践与服务, 2024, 42(7): 297-304, 314. doi: 10.12206/j.issn.2097-2024.202310057
[3]	姚小静, 计佩影, 陆峰, 施国荣, 傅翔. 表面增强拉曼光谱法快速测定尿液中曲马多的研究 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202401072
[4]	马兹芬, 许维恒, 金煜翔, 薛磊. 食管癌的靶向治疗与免疫治疗研究进展 . 药学实践与服务, 2024, 42(6): 231-237. doi: 10.12206/j.issn.2097-2024.202306008
[5]	徐飞, 陈瑾, 鲁育含, 李志勇. 肠道菌群参与糖尿病肾病的机制研究进展 . 药学实践与服务, 2024, 42(5): 181-184, 197. doi: 10.12206/j.issn.2097-2024.202312023
[6]	杨凤艳, 张月, 陈恩贤, 缪雪蓉, 魏凯. 瑞马唑仑临床应用研究进展 . 药学实践与服务, 2024, 42(9): 365-374. doi: 10.12206/j.issn.2097-2024.202405026
[7]	陈莹, 许子华, 胡北, 崔亚玲, 高欢, 吴琼. 通便灵胶囊治疗便秘的药效与机制研究 . 药学实践与服务, 2024, 42(): 1-7. doi: 10.12206/j.issn.2097-2024.202404008
[8]	张元林, 宋凯, 孙蕊, 舒飞, 舒丽芯, 杨樟卫. 基于真实世界数据的药物利用研究综述 . 药学实践与服务, 2024, 42(6): 238-243. doi: 10.12206/j.issn.2097-2024.202312010
[9]	张林晨, 张小琴, 张俊平. 山楂酸药理作用的研究进展 . 药学实践与服务, 2024, 42(5): 185-189. doi: 10.12206/j.issn.2097-2024.202307052
[10]	宋泽成, 陈林林, 鲁仁义, 刘梦肖, 王彦. 脓毒症治疗的研究进展 . 药学实践与服务, 2024, 42(11): 457-460, 502. doi: 10.12206/j.issn.2097-2024.202405059
[11]	崔俐俊, 陈嫣婷, 费永和, 陈静. 中外药品应急审批制度对比研究 . 药学实践与服务, 2024, 42(8): 359-364. doi: 10.12206/j.issn.2097-2024.202310015
[12]	杨嘉宁, 赵一颖, 肖伟. 七味脂肝方对非酒精性脂肪性肝炎动物模型的药效学评价 . 药学实践与服务, 2024, 42(9): 389-398. doi: 10.12206/j.issn.2097-2024.202404096
[13]	宋雨桐, 夏德润, 顾珩, 唐少文, 易洪刚, 沃红梅. 帕博利珠单抗与铂类化疗方案在晚期非小细胞肺癌一线治疗中的药物经济学评价 . 药学实践与服务, 2024, 42(8): 334-340. doi: 10.12206/j.issn.2097-2024.202303023
[14]	夏哲炜, 曾垣烨, 朱海菲, 李育, 陈啸飞. 核磁共振磷谱法测定磷酸氢钙咀嚼片中药物含量 . 药学实践与服务, 2024, 42(9): 399-401, 406. doi: 10.12206/j.issn.2097-2024.202404063
[15]	顾佳钰, 胡馨儿, 王晓飞, 张颖, 张海, 曹岩. 侧流免疫层析定量检测方法的研究进展 . 药学实践与服务, 2024, 42(7): 273-277, 284. doi: 10.12206/j.issn.2097-2024.202307037
[16]	赖立勇, 夏天爽, 徐圣焱, 蒋益萍, 岳小强, 辛海量. 中药青蒿抗氧化活性的谱效关系研究 . 药学实践与服务, 2024, 42(5): 203-210, 216. doi: 10.12206/j.issn.2097-2024.202211012
[17]	何静, 安晔, 张朝绅. 复方黑参滴丸与复方黑参丸药效学实验比较研究 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202404009
[18]	崔亚玲, 吴琼, 马良煜, 胡北, 姚东, 许子华. 肝素钠肌醇烟酸酯乳膏中肌醇烟酸酯皮肤药动学研究 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202404006
[19]	陈炳辰, 佟达丰, 万苗, 闫飞虎, 姚建忠. UPLC-MS/MS法测定小鼠血浆中紫杉醇脂肪酸酯前药及其药代动力学研究 . 药学实践与服务, 2024, 42(8): 341-345. doi: 10.12206/j.issn.2097-2024.202404082
[20]	张艺昕, 关欣怡, 王博宁, 闻俊, 洪战英. 二氢吡啶类钙离子拮抗药物手性分析及其立体选择性药动学研究进展 . 药学实践与服务, 2024, 42(8): 319-324. doi: 10.12206/j.issn.2097-2024.202308062

点击查看大图

计量

文章访问数: 3425
HTML全文浏览量: 435
PDF下载量: 284
被引次数: 0

姓名
邮箱
手机号码
标题
留言内容
验证码

留言板

中药复方药动学研究方法概述

doi: 10.3969/j.issn.1006-0111.2015.01.002

Summary of the pharmacokinetic methods of traditional Chinese medicine prescription

计量

中药复方药动学研究方法概述

doi: 10.3969/j.issn.1006-0111.2015.01.002

1. 上海交通大学药学院, 上海 200240

2. 第二军医大学药学院天然药物化学教研室, 上海 200433

English Abstract

Summary of the pharmacokinetic methods of traditional Chinese medicine prescription

1. School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China

2. Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

全文HTML

目录

留言板

中药复方药动学研究方法概述

doi: 10.3969/j.issn.1006-0111.2015.01.002

Summary of the pharmacokinetic methods of traditional Chinese medicine prescription

计量

出版历程

中药复方药动学研究方法概述

doi: 10.3969/j.issn.1006-0111.2015.01.002

1. 上海交通大学药学院, 上海 200240 2. 第二军医大学药学院天然药物化学教研室, 上海 200433

English Abstract

Summary of the pharmacokinetic methods of traditional Chinese medicine prescription

1. School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China 2. Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

全文HTML

目录

1. 上海交通大学药学院, 上海 200240

2. 第二军医大学药学院天然药物化学教研室, 上海 200433

1. School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China

2. Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China