秦艽总环烯醚萜苷的抗炎作用及其机制

牛筛龙; 孙富增; 张兴耐

doi:10.3969/j.issn.1006-0111.2013.03.010

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

x 关闭永久关闭

应中央军委要求，2022年9月起，《药学实践杂志》将更名为《药学实践与服务》，双月刊，正文96页；2023年1月起，拟出版月刊，正文64页，数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿！

秦艽总环烯醚萜苷的抗炎作用及其机制

牛筛龙, 孙富增, 张兴耐

文章导航 > 药学实践与服务 > 2013 > 31(3): 198-200

牛筛龙, 孙富增, 张兴耐. 秦艽总环烯醚萜苷的抗炎作用及其机制[J]. 药学实践与服务, 2013, 31(3): 198-200. doi: 10.3969/j.issn.1006-0111.2013.03.010

引用本文:

牛筛龙, 孙富增, 张兴耐. 秦艽总环烯醚萜苷的抗炎作用及其机制[J]. 药学实践与服务, 2013, 31(3): 198-200. doi: 10.3969/j.issn.1006-0111.2013.03.010

NIU Shai-long, SUN Fu-zeng, Zhang Xing-nai. Anti-inflammatory mechanisms of Gentiana macrophylla iridoid glucoside[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(3): 198-200. doi: 10.3969/j.issn.1006-0111.2013.03.010

Citation:

NIU Shai-long, SUN Fu-zeng, Zhang Xing-nai. Anti-inflammatory mechanisms of Gentiana macrophylla iridoid glucoside[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(3): 198-200. doi: 10.3969/j.issn.1006-0111.2013.03.010

秦艽总环烯醚萜苷的抗炎作用及其机制

doi: 10.3969/j.issn.1006-0111.2013.03.010

武警江苏省总队医院药剂科, 江苏扬州 225003

Anti-inflammatory mechanisms of Gentiana macrophylla iridoid glucoside

Department of Pharmacy, Jiangsu Provincial Corps Hospital of Chinese People's Armed Police Forces, Yangzhou 225003, China

摘要: 目的观察不同浓度秦艽总环烯醚萜(GMI)对各型各期炎症模型的影响,探讨其抗炎作用的可能机制。方法采用二甲苯致耳廓肿胀、醋酸诱发小鼠腹腔毛细血管通透性增高,蛋清致大鼠背部气囊滑膜炎,棉球诱发小鼠肉芽肿模型,探讨GMI的抗炎作用。称体质量测定各组小鼠耳的炎症肿胀程度及肉芽增生水平,用化学方法检测各组小鼠腹腔洗涤液中的伊文思蓝含量、滑膜炎渗出液容积、渗出液中的白细胞(WBC)计数和肿瘤坏死因子(TNF-α)含量,渗出液和血清中超氧化物歧化酶(SOD)、丙二醛(MDA)含量。 结果与结论 与阴性对照组相比,GMI能够抑制二甲苯致小鼠耳廓肿胀、醋酸致小鼠毛细血管通透性的增加,以及小鼠棉球肉芽肿的形成;其较阴性对照组还能明显减少渗出液容积,降低渗出液中WBC、MDA、TNF-α含量及血清中MDA水平,并能提高渗出液和血清中SOD的活性。结论 GMI能够减轻各期炎症形成,机制可能与抑制炎性因子的渗出、消除自由基和抑制脂质过氧化有关。
- 秦艽 /
- 总环烯醚萜苷 /
- 抗炎 /
- 作用机制
Abstract: Objective To observe effects of different concentrations of the Gentiana macrophylla iridoid glucoside(GMI) in different period inflammatory models, and discuss the possibility of anti-inflammation. Methods The anti-inflammatory models of GMI were investigated in mice by methods of the capillary permeability increase (AIPCPI), the cotton-pellet induced-granuloma(CPIG) xylene-induced auricle swelling (XIAS), intraperitoneal injection of acetic acid-induced peritoneal capilnd egg white-induced balloon back synovial inflammation. Levels of XIAS and CPIG in mouse were detected by weighing. Levels of mouse peritoneal washing fluid in the content of Evans blue, synovitis exudate volume, white blood cells(WBC), tumor necrosis factor(TNF-α), the exudate and serum levels of superoxide dismutase(SOD) and malondialdehyde were determined by chemical method respectively. Result Compared with negative control group, levels of XIAS, AIPCPI and CPIG decreased significantly in GMI group. Levels of WBC, MDA and TNF-α significantly decreased in GMI group than those of negative control group, but the activity of the exudate and serum SOD increased significantly in GMI group compared with that of negative control group. Conclusion The GMI showed protective effects on inflammation in animal models, which might be mediated through inhibition of the exudation of inflammatory factors, the lipid peroxidation and the elimination of free radicals.
- G. macrophylla Pall /
- iridoid glucoside /
- anti-inflammatory /
- mechanism

[1]	中国科学院中国植物志编辑委员会.中国植物志,第1版[M].北京:科学出版社,1988:62.
[2]	Tan Rx,Wolfender JL,Zhang LX,et al.Acyl secoiridiods and antifungal constituents from Gentiana macrophylla[J].Phytochem,1996,42(5):1305.
[3]	刘艳红, 李兴从, 刘玉清, 等. 秦艽中的环烯醚萜苷类成分[J].云南植物研究, 1995, 15(1):85.
[4]	张均智,莫刚,杨成芳,等. 茅莓正丁醇组分的抗炎作用[J].中国实验方剂学杂志,2011,17(8):204.
[5]	钱海兵,蒲金山,王龙,等.苗药铁筷子挥发油的抗炎作用研究[J].时珍国医国药,2012,23(8):1961.
[6]	王玮, 白月, 王俊平, 等. 黄芩茎叶总黄酮对大鼠气囊滑膜炎抗炎作用机制的研究[J]. 临床与用药, 2009, 26(4):460.
[7]	韩磊, 向云霞, 徐磊. 中药抗炎与免疫药理[J]. 新疆中医药, 2011, 29(4):114.

[1]	冯志惠, 邓仪卿, 叶冰, 安培, 张宏, 张海军. 雀梅藤石油醚提取物诱导三阴性乳腺癌细胞凋亡的实验研究 . 药学实践与服务, 2024, 42(6): 253-259. doi: 10.12206/j.issn.2097-2024.202311055
[2]	陈金涛, 乔子婴, 马明华, 张若曦, 王振伟, 年华. 基于网络药理学和分子对接技术研究金芪清疏颗粒治疗社区获得性肺炎的潜在机制 . 药学实践与服务, 2024, 42(11): 471-478. doi: 10.12206/j.issn.2097-2024.202312014
[3]	杨媛媛, 安晓强, 许佳捷, 江键, 梁媛媛. 正极性驻极体联合5-氟尿嘧啶对瘢痕成纤维细胞生长抑制的协同作用 . 药学实践与服务, 2024, 42(6): 244-247. doi: 10.12206/j.issn.2097-2024.202310027
[4]	温瑞睿, 许龙, 朱文静, 杨建伟. 浅谈国外药师主导开展戒烟服务的作用与挑战 . 药学实践与服务, 2024, 42(): 1-6. doi: 10.12206/j.issn.2097-2024.202408054
[5]	张修平, 田家盛, 王道鑫, 李佳鑫, 王品, 缪朝玉. MT-1207对小鼠血糖、血脂和动脉粥样硬化的作用 . 药学实践与服务, 2024, 42(11): 487-494. doi: 10.12206/j.issn.2097-2024.202306011
[6]	钱淑雨, 李铁军. 耐碳青霉烯类肠杆菌耐药机制的研究进展 . 药学实践与服务, 2024, 42(10): 419-425. doi: 10.12206/j.issn.2097-2024.202405005
[7]	杨彬, 王作君, 陈菡, 张敬一. 基于DRGs的医院合理用药管理机制探索实践 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202404030
[8]	徐飞, 陈瑾, 鲁育含, 李志勇. 肠道菌群参与糖尿病肾病的机制研究进展 . 药学实践与服务, 2024, 42(5): 181-184, 197. doi: 10.12206/j.issn.2097-2024.202312023
[9]	陈莹, 许子华, 胡北, 崔亚玲, 高欢, 吴琼. 通便灵胶囊治疗便秘的药效与机制研究 . 药学实践与服务, 2024, 42(): 1-7. doi: 10.12206/j.issn.2097-2024.202404008
[10]	丁华敏, 郭羽晨, 秦春霞, 宋志兵, 孙莉莉. 消风止痒颗粒通过降低白三烯水平对小鼠特应性皮炎急性瘙痒的治疗作用研究 . 药学实践与服务, 2024, 42(5): 211-216. doi: 10.12206/j.issn.2097-2024.202306031
[11]	徐璐璐, 刘爱军. 丹参白术方“异病同治”冠心病、血管性痴呆、特发性膜性肾病的网络药理学作用机制研究 . 药学实践与服务, 2024, 42(12): 1-8. doi: 10.12206/j.issn.2097-2024.202312027
[12]	张广雨, 杜晶, 刘梦珍, 朱丹妮, 闫慧, 刘冲. 新斯的明与山莨菪碱联合应用对肺型氧中毒的保护作用及其机制的研究 . 药学实践与服务, 2024, 42(10): 433-438, 444. doi: 10.12206/j.issn.2097-2024.202310049
[13]	岳春华, 贲永光, 王海桥. 基于NLRP1炎症小体探讨百合知母汤抗抑郁的作用机制 . 药学实践与服务, 2024, 42(8): 325-333. doi: 10.12206/j.issn.2097-2024.202401033
[14]	修建平, 杨朝爱, 刘禧澳, 潘乾禹, 韦广旭, 王卫星. 全反式维甲酸对肝星状细胞活化及氧化应激的作用和机制探索 . 药学实践与服务, 2024, 42(7): 291-296. doi: 10.12206/j.issn.2097-2024.202312054
[15]	姜涛, 徐卫凡, 蒋益萍, 夏天爽, 辛海量. 巴戟天丸组方对Aβ损伤成骨细胞的作用及基于网络药理学的机制研究 . 药学实践与服务, 2024, 42(7): 285-290, 296. doi: 10.12206/j.issn.2097-2024.202305011
[16]	李清, 郭宜银, 陈颖, 瞿发林, 董文燊, 戈煜. 夜宁胶囊对小鼠镇静催眠作用及其机制的研究 . 药学实践与服务, 2024, 42(8): 346-349. doi: 10.12206/j.issn.2097-2024.202211047
[17]	郭灵怡, 刘艳超, 高路, 刘瑞瑶, 吕权真, 俞媛. 醋酸卡泊芬净单硬脂酸甘油酯纳米粒抗白色念珠菌感染的增效作用研究 . 药学实践与服务, 2024, 42(): 1-8. doi: 10.12206/j.issn.2097-2024.202310043
[18]	景凯, 杨慈荣, 张圳, 臧艺蓓, 刘霞. 黄芪甲苷衍生物治疗慢性心力衰竭小鼠的药效评价及作用机制研究 . 药学实践与服务, 2024, 42(5): 190-197. doi: 10.12206/j.issn.2097-2024.202310004
[19]	张林晨, 张小琴, 张俊平. 山楂酸药理作用的研究进展 . 药学实践与服务, 2024, 42(5): 185-189. doi: 10.12206/j.issn.2097-2024.202307052
[20]	陈静, 何瑞华, 翁月, 徐熠, 刘静, 黄瑾. 基于网络药理学和分子对接技术探究定清片活性成分治疗白血病的作用机制 . 药学实践与服务, 2024, 42(11): 479-486. doi: 10.12206/j.issn.2097-2024.202401073

点击查看大图

计量

文章访问数: 4149
HTML全文浏览量: 471
PDF下载量: 72
被引次数: 0

秦艽总环烯醚萜苷的抗炎作用及其机制

doi: 10.3969/j.issn.1006-0111.2013.03.010

武警江苏省总队医院药剂科, 江苏扬州 225003

收稿日期: 2012-11-20
修回日期: 2013-04-10

关键词:

秦艽 /

总环烯醚萜苷 /

抗炎 /

作用机制

摘要: 目的观察不同浓度秦艽总环烯醚萜(GMI)对各型各期炎症模型的影响,探讨其抗炎作用的可能机制。方法采用二甲苯致耳廓肿胀、醋酸诱发小鼠腹腔毛细血管通透性增高,蛋清致大鼠背部气囊滑膜炎,棉球诱发小鼠肉芽肿模型,探讨GMI的抗炎作用。称体质量测定各组小鼠耳的炎症肿胀程度及肉芽增生水平,用化学方法检测各组小鼠腹腔洗涤液中的伊文思蓝含量、滑膜炎渗出液容积、渗出液中的白细胞(WBC)计数和肿瘤坏死因子(TNF-α)含量,渗出液和血清中超氧化物歧化酶(SOD)、丙二醛(MDA)含量。 结果与结论 与阴性对照组相比,GMI能够抑制二甲苯致小鼠耳廓肿胀、醋酸致小鼠毛细血管通透性的增加,以及小鼠棉球肉芽肿的形成;其较阴性对照组还能明显减少渗出液容积,降低渗出液中WBC、MDA、TNF-α含量及血清中MDA水平,并能提高渗出液和血清中SOD的活性。结论 GMI能够减轻各期炎症形成,机制可能与抑制炎性因子的渗出、消除自由基和抑制脂质过氧化有关。

English Abstract

Anti-inflammatory mechanisms of Gentiana macrophylla iridoid glucoside

Department of Pharmacy, Jiangsu Provincial Corps Hospital of Chinese People's Armed Police Forces, Yangzhou 225003, China

Received Date: 2012-11-20
Rev Recd Date: 2013-04-10

Keywords:

Abstract: Objective To observe effects of different concentrations of the Gentiana macrophylla iridoid glucoside(GMI) in different period inflammatory models, and discuss the possibility of anti-inflammation. Methods The anti-inflammatory models of GMI were investigated in mice by methods of the capillary permeability increase (AIPCPI), the cotton-pellet induced-granuloma(CPIG) xylene-induced auricle swelling (XIAS), intraperitoneal injection of acetic acid-induced peritoneal capilnd egg white-induced balloon back synovial inflammation. Levels of XIAS and CPIG in mouse were detected by weighing. Levels of mouse peritoneal washing fluid in the content of Evans blue, synovitis exudate volume, white blood cells(WBC), tumor necrosis factor(TNF-α), the exudate and serum levels of superoxide dismutase(SOD) and malondialdehyde were determined by chemical method respectively. Result Compared with negative control group, levels of XIAS, AIPCPI and CPIG decreased significantly in GMI group. Levels of WBC, MDA and TNF-α significantly decreased in GMI group than those of negative control group, but the activity of the exudate and serum SOD increased significantly in GMI group compared with that of negative control group. Conclusion The GMI showed protective effects on inflammation in animal models, which might be mediated through inhibition of the exudation of inflammatory factors, the lipid peroxidation and the elimination of free radicals.

牛筛龙, 孙富增, 张兴耐. 秦艽总环烯醚萜苷的抗炎作用及其机制[J]. 药学实践与服务, 2013, 31(3): 198-200. doi: 10.3969/j.issn.1006-0111.2013.03.010

引用本文:

牛筛龙, 孙富增, 张兴耐. 秦艽总环烯醚萜苷的抗炎作用及其机制[J]. 药学实践与服务, 2013, 31(3): 198-200. doi: 10.3969/j.issn.1006-0111.2013.03.010

Citation: