Comparison of two different methods for preparation inclusion compound of β-cyclodextrin with Peppermint Oil
-
摘要: 目的 比较饱和水溶液法和超声法制备薄荷油β-环糊精包合物的工艺。 方法 选用适量薄荷药材,提取薄荷油,分别用饱和水溶液法和超声法制备薄荷油β-环糊精包合物。 结果 与超声法相比,饱和水溶液法制备薄荷油β-环糊精包合率和包合物的收率均较高;并通过正交试验确定了饱和水溶液法最佳包合工艺为薄荷油(ml):β-环糊精(g)为1:5、搅拌时间为1 h、包合温度45℃,β-环糊精(g):水(ml)为1:10。 结论 优选的饱和水溶液法包合工艺合理、结果较好,并且操作更为简便。
-
关键词:
- 薄荷油β-环糊精包合物 /
- 饱和水溶液法 /
- 超声法
Abstract: Objective To compare the methods of saturated water solution and ultrasonic for preparation inclusion compound of β-cyclodextrin with peppermint oil. Methods After extraction of peppermint oil, the inclusion compound of β-cyclodextrin with peppermint oil was prepared by saturated water solution method and ultrasonic method. Results The better inclusion method was saturated water solution with higher inclusion rate and yield of inclusion compound. And the optimum inclusion conditions were as follows:peppermint oil(ml):β-cyclodextrin(g)=1:5, stirring for 1 hour, 45℃, β-cyclodextrin(g):water(ml)=1:10. Conclusion The better inclusion method was saturated water solution which was reasonable and convenient. -
[1] 叶卯祥,严雪黎.β-环糊精包合技术在中药挥发油制剂中的应用研究[J].医学综述, 2010,16(24):3793. [2] 罗国平,樊俊红.白术、枳实、玫瑰花挥发油-β-环糊精包合物的制备工艺研究[J].药品评价,2005,2(2):131. [3] 钟秀英.药用β-环糊精包合物制备、检验技术研究进展[J].中药材,2003,26(4):262. -
点击查看大图
计量
- 文章访问数: 2954
- HTML全文浏览量: 331
- PDF下载量: 123
- 被引次数: 0
下载:
