洛匹那韦药代动力学的研究进展

姚亚敏; 沐俊; 孙骥; 马芳; 卢洪洲; 张丽军

doi:10.3969/j.issn.1006-0111.2012.05.005

洛匹那韦药代动力学的研究进展

doi: 10.3969/j.issn.1006-0111.2012.05.005

1.
上海市公共卫生临床中心, 上海 201508
2.
苏州大学医学部, 江苏苏州 215123

基金项目: 抗艾滋病病毒新药临床评价研究技术平台建设(2012ZX09303013);成人艾滋病适宜治疗策略研究与应用(2012ZX10001003)

Progress on pharmacokinetics of lopinavir

1.
Shanghai Public Health Clinical Center, Shanghai 201508, China
2.
Medical College of Suzhou University, Suzhou 215123, China

摘要: 洛匹那韦作为第二代蛋白酶抑制剂,在艾滋病治疗领域得到广泛应用。然而,该药能被代谢酶CYP3A4快速代谢,在临床应用中,存在较大的个体差异。因此,对洛匹那韦进行药代动力学分析,了解其血药浓度与疗效以及不良反应的关系对优化临床用药具有重要意义。本文全面综述了近年来洛匹那韦浓度分析方法、药代动力学研究进展,为日后洛匹那韦治疗药物监测以及个体化用药研究提供归纳总结材料。
- 洛匹那韦 /
- 艾滋病 /
- 蛋白酶抑制剂 /
- 药代动力学
Abstract: Lopinavir was widely used as a second generation protease inhibitor in AIDS therapy, which was quickly metabolized by CYP3A4. For individual variance might lead to different metabolism, it was important to study the pharmacokinetic parameters of lopinavir and learn the relationship between drug concentration and curative effect or adverse reactions. The methods for determining lopinavir concentration and the progress of pharmacokinetic research were reviewed in this paper which might offer some help for treatment drug monitoring (TDM) and personalized dosage research.
- lopinavir /
- AIDS /
- protease inhibitor /
- pharmacokinetics

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洛匹那韦药代动力学的研究进展

doi: 10.3969/j.issn.1006-0111.2012.05.005

Progress on pharmacokinetics of lopinavir

计量

洛匹那韦药代动力学的研究进展

doi: 10.3969/j.issn.1006-0111.2012.05.005

1. 上海市公共卫生临床中心, 上海 201508

2. 苏州大学医学部, 江苏苏州 215123

English Abstract

Progress on pharmacokinetics of lopinavir

1. Shanghai Public Health Clinical Center, Shanghai 201508, China

2. Medical College of Suzhou University, Suzhou 215123, China

全文HTML

目录

留言板

洛匹那韦药代动力学的研究进展

doi: 10.3969/j.issn.1006-0111.2012.05.005

Progress on pharmacokinetics of lopinavir

计量

出版历程

洛匹那韦药代动力学的研究进展

doi: 10.3969/j.issn.1006-0111.2012.05.005

1. 上海市公共卫生临床中心, 上海 201508 2. 苏州大学医学部, 江苏 苏州 215123

English Abstract

Progress on pharmacokinetics of lopinavir

1. Shanghai Public Health Clinical Center, Shanghai 201508, China 2. Medical College of Suzhou University, Suzhou 215123, China

全文HTML

目录

1. 上海市公共卫生临床中心, 上海 201508

2. 苏州大学医学部, 江苏苏州 215123

1. Shanghai Public Health Clinical Center, Shanghai 201508, China

2. Medical College of Suzhou University, Suzhou 215123, China