核糖体蛋白S3a在肿瘤细胞增殖分化和凋亡调控作用的研究概况

李英华; 胡振林; 张俊平

doi:10.3969/j.issn.1006-0111.2012.03.003

核糖体蛋白S3a在肿瘤细胞增殖分化和凋亡调控作用的研究概况

doi: 10.3969/j.issn.1006-0111.2012.03.003

第二军医大学药学院生化药学教研室,上海 200433

基金项目: 国家自然科学基金(91013014 ).

Progress on the role of Ribosomal Protein S3a in regulation of proliferation, differentiation and apoptosis in tumor cells

Department of Biochemical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433 China

摘要: 目的综述核糖体蛋白S3a在肿瘤细胞增殖分化和凋亡调控作用的研究进展。方法参阅近几年国内外相关文献,对核糖体蛋白S3a的结构、功能及其异常表达对肿瘤细胞增殖分化和凋亡的调控等方面的进展进行归纳总结。结果与结论核糖体蛋白S3a除了在蛋白质合成中起重要作用外,还有独特的核糖体外功能。其在多种肿瘤细胞中高表达,通过调控癌基因和抑癌基因的表达可影响肿瘤细胞的增殖分化与凋亡。
- 核糖体蛋白S3a /
- 肿瘤细胞 /
- 增殖 /
- 分化与凋亡
Abstract: Objective To review the role of Ribosomal Protein S3a in regulation of proliferation, differentiation and apoptosis in tumor cells. Methods The relevant literatures were collected to make a summary of Ribosomal Protein S3a in regulation of proliferation, differentiation and apoptosis in tumor cells. Result and Conclusion Ribosomal Protein S3a played an important role in protein synthesis and also had unique extra-ribosomal functions, such as DNA repair, cell growth and cell differentiation. In recent years, it was found that the expression of Ribosomal Protein S3a was enhancedin tumor cells. It was involved in the regulation of proliferation, differentiation, and apoptosis of tumor cells by affecting the expression of oncogenes and tumor suppressor genes.
- Ribosomal Protein S3a /
- tumor cell /
- proliferation /
- differentiation and apoptosis

[1]	Lindstrom MS. Emerging functions of ribosomal proteins in gene-specific transcription and translation[J]. Biochem Biophys Res Commun,2009,379(2):167.
[2]	Dai MS, Sears R. Feedback regulation of c-Myc by ribosomal protein L11[J]. Cell Cycle, 2007,6:2735.
[3]	Khanna N, Sen S, Sharma H,et al. S29 ribosomal protein induces apoptosis in H520 cells and sensitizes them to chemotherapy[J]. Biochem Biophys Res Commun,2003,304:26.
[4]	Wan F, Anderson DE, Barnitz RA,et al. Ribosomal protein S3:KH domain subunit in NF-kappaB complexes that mediates selective gene regulation[J]. Cell,2007,131:927.
[5]	Kho CJ. Fte-1, a v-fos transformation effector gene, encodes the mammalian homologue of a yeast gene involved in protein import into mitochondria[J]. PNAS, 1992,89: 2200.
[6]	Lecomte F. The S3a ribosomal protein gene is identical to the Fte-1(v-fos transformation effector) gene and the TNF-alpha-induced TU-11 gene, and its transcript level is altered in transformed and tumor cells[J]. Gene 1997,186(2): 271.
[7]	Naora H, Nishida T, Shindo Y, et al. Association of nbl gene expression and glucocorticoid induced apoptosis in mouse thymus in vivo[J]. Immunology, 1995,85(1): 63.
[8]	Nygard O,Nilsson L. Translational dynamics:interactions between the translational factors, tRNA and ribosomes during eucaryotic protein synthesis[J]. Eur J Biochem, 1990,191:1.
[9]	Tarantul VZ, Nikolaev AI. Differential gene expression in B-cell non-Hodgkin's lymphoma of SIV-infected monkey[J]. AIDS Res Hum Retroviruses, 2000,16(2):173.
[10]	Zhu HX, Zhai BJ. Establishent and clinical significance of the gene expression map of normal peripheral blood mononuclear cells[J]. Tianjin Med J,2008,36(11):856.
[11]	Slizhikova DK, Vinogradova TV. The NOLA2 and RPS3a genes as highly informative markers for human squamous cell lung cancer[J]. Bioorg Khim, 2005 ,31(2):195.
[12]	Angelastro JM, Torocsik B, Greene LA. Nerve growth factor selectively regeulates expressionof transcripts encoding ribosomal proteins[J]. BMC Neuroscience,2002,3(1):3 .
[13]	Zhou ZD, Lei B, Liu DG,et al. Low content of protein S29 in ribosomes of human lung cancer cell line A549:detected by two-dimensional electrophoresis[J]. Protein Pept Lett,2003,10(1);91.
[14]	Jeremy L,Goodin,Charles L,et al. Characterization of human ribosomal S3a gene expression during adenosine 3:5cyclic monophosphate induced neuroendocrine differentiation of LNCaP cells. Regulation of S3a gene expression in LNCaP[J]. Molecular Biology Reports, 2002,29: 301.
[15]	Kho CJ, Wang Y, Zarbl H,et al. Effect of decreased fte-1 gene expression on protein synthesis, cell growth, and transformation [J]. Cell Growth Differ, 1996, 7(9): 1157.
[16]	Pandolfi PP. Dose the ribosome transelate cancer[J]. Nat Rev Cancer, 2003,3(3):179.
[17]	Ira G,Wool.Extraribosomal functions of ribosomal proteins[J].Trends Biochem Sci,1996,21:164.
[18]	Cui K , Margaret Coutts, Joachim Stahl,et al. Novel interaction between the transcription factor CHOP(GADD153) and the ribosomal protein FTE/S3a modulates erythropoiesis[J]. J Biol Chem ,2000,275(11):7591.
[19]	Naora H,Nishida T,Shindo Y. Constitutively enhanced nbl expression is associated with the induction of internuclesomal DNA cleavage by actinomycine D[J]. Biochem Biophys Res Commun,1996,224(1):258.
[20]	Russell L,Naora H. Down-regulated RPS3a/nbl expression during retinoid-induced differentiation of HL-60 cells: A close association with diminished susceptibility to actinomycin D-stimulated apoptosis[J]. Cell Struct Funct, 2000,25(2): 103.
[21]	Naora H. Involvement of ribosomal proteins in regulating cell growth and apoptosis: translational modulation or recruitment for extraribosomal activity[J]. Immunol Cell Biol, 1999,77(3): 197.
[22]	Naora H, Takai I, Adachi M, et al. Altered cellular responses by varying expression of a ribosomal protein gene: Sequential coor-dination of enhancement and suppression of ribosomal protein S3a gene expression induces apoptosis[J]. J Cell Biol,1998,141(3):741.
[23]	Naora H,Nishida T,Shindo Y. Antisense sequences of nbl gene induce apoptosis in the human promyelocytic leukemia cell line HL-60[J]. Leukemia ,1998,12:532.
[24]	Hu ZB, Minden MD, McCulloch EA,et al. Regulation of drug sensibility by ribosomal protein S3a[J]. Blood, 2000,95(3): 1047.
[25]	Demao S, Shuji S,Taketoshi T,et al. Inhibition of poly(ADP-ribose) polymerase activity by Bcl-2 in association with the Ribosomal Protein S3a[J]. Biochem, 2002,41 (3), 929.
[26]	Elena K, Mariya Y,Krisztina S, et al. Epstein-Barr virus-encoded EBNA-5 binds to Epstein-Barr virus-induced Fte1/S3a protein[J]. Exp Cell Res,2005,303:47.
[27]	缪扣荣,徐卫,李建勇. p53基因信号通路的新成员miRNA[J]. 中国实验血液学杂志,2009,17(2):500.
[28]	Aparicio S, Eaves CJ. p53: a new kingpin in the stem cell arena[J]. Cell,2009,138(6):1060.
[29]	徐恩相,李峰. p14^ARF、p53蛋白与脑胶质瘤发生发展的相关性研究[J].实用全科医学,2007,5(5):390.

[1]	毛智毅, 王筱燕, 陈晓颖, 汤逸斐. 度拉糖肽联合二甲双胍对肥胖型2型糖尿病患者机体代谢、体脂成分及血清脂肪因子的影响 . 药学实践与服务, 2024, 42(7): 305-309. doi: 10.12206/j.issn.2097-2024.202305032
[2]	张莲卿, 骆岩, 杨提, 姚佳晨, 李文艳. 基于FAERS数据库的艾塞那肽微球不良事件信号挖掘与研究 . 药学实践与服务, 2024, 42(10): 445-450. doi: 10.12206/j.issn.2097-2024.202403057
[3]	温瑞睿, 许龙, 朱文静, 杨建伟. 浅谈国外药师主导开展戒烟服务的作用与挑战 . 药学实践与服务, 2024, 42(): 1-6. doi: 10.12206/j.issn.2097-2024.202408054
[4]	孙丹倪, 黄勇, 张嘉宝, 王培. 代谢相关脂肪性肝病的无创诊断与药物治疗 . 药学实践与服务, 2024, 42(10): 411-418. doi: 10.12206/j.issn.2097-2024.202403049
[5]	韩丹, 高文, 王璐暖, 孙蕊, 郭明明, 舒丽芯. 美国FDA有关药品紧急授权的实践与启示 . 药学实践与服务, 2024, 42(): 1-4. doi: 10.12206/j.issn.2097-2024.202309044
[6]	陈炳辰, 王思真, 郭贝贝, 杨峰. 紫杉醇棕榈酸酯的合成及其脂质体的制备与处方研究 . 药学实践与服务, 2024, 42(9): 379-384, 410. doi: 10.12206/j.issn.2097-2024.202404062
[7]	何静, 安晔, 张朝绅. 复方黑参滴丸与复方黑参丸药效学实验比较研究 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202404009
[8]	张成中, 朱雪艳, 卜其涛, 王宏瑞, 黄宝康. 基于网络药理学与分子对接预测鸡骨草特征图谱研究 . 药学实践与服务, 2024, 42(8): 350-358. doi: 10.12206/j.issn.2097-2024.202303048
[9]	马兹芬, 许维恒, 金煜翔, 薛磊. 食管癌的靶向治疗与免疫治疗研究进展 . 药学实践与服务, 2024, 42(6): 231-237. doi: 10.12206/j.issn.2097-2024.202306008
[10]	王雪莲, 郑斯莉, 李志勇, 罗亨宇, 缪朝玉. 全身过表达人METRNL基因小鼠模型的构建与验证 . 药学实践与服务, 2024, 42(5): 198-202, 222. doi: 10.12206/j.issn.2097-2024.202311014
[11]	陈莹, 许子华, 胡北, 崔亚玲, 高欢, 吴琼. 通便灵胶囊治疗便秘的药效与机制研究 . 药学实践与服务, 2024, 42(): 1-7. doi: 10.12206/j.issn.2097-2024.202404008
[12]	刘汝雄, 杨万镇, 涂杰, 盛春泉. 铁死亡调控蛋白GPX4的小分子抑制剂研究进展 . 药学实践与服务, 2024, 42(9): 375-378. doi: 10.12206/j.issn.2097-2024.202312075
[13]	刘丽艳, 余小翠, 孙传铎. 纳武利尤单抗治疗非小细胞肺癌有效性及安全性的Meta分析 . 药学实践与服务, 2024, 42(10): 451-456. doi: 10.12206/j.issn.2097-2024.202310044
[14]	迟文雅, 袁艳, 李伟林, 吴茼妤, 俞媛. 负载骨髓间充质干细胞/白藜芦醇脂质体的水凝胶支架用于创伤性脑损伤治疗 . 药学实践与服务, 2024, 42(): 1-8. doi: 10.12206/j.issn.2097-2024.202406034
[15]	修建平, 杨朝爱, 刘禧澳, 潘乾禹, 韦广旭, 王卫星. 全反式维甲酸对肝星状细胞活化及氧化应激的作用和机制探索 . 药学实践与服务, 2024, 42(7): 291-296. doi: 10.12206/j.issn.2097-2024.202312054
[16]	姜涛, 徐卫凡, 蒋益萍, 夏天爽, 辛海量. 巴戟天丸组方对Aβ损伤成骨细胞的作用及基于网络药理学的机制研究 . 药学实践与服务, 2024, 42(7): 285-290, 296. doi: 10.12206/j.issn.2097-2024.202305011
[17]	杨媛媛, 安晓强, 许佳捷, 江键, 梁媛媛. 正极性驻极体联合5-氟尿嘧啶对瘢痕成纤维细胞生长抑制的协同作用 . 药学实践与服务, 2024, 42(6): 244-247. doi: 10.12206/j.issn.2097-2024.202310027
[18]	桂明珠, 李静, 李志玲. 儿童伏立康唑的血药浓度与CYP2C19、CYP2C9和CYP3A5基因多态性的相关性研究 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202402020
[19]	宋雨桐, 夏德润, 顾珩, 唐少文, 易洪刚, 沃红梅. 帕博利珠单抗与铂类化疗方案在晚期非小细胞肺癌一线治疗中的药物经济学评价 . 药学实践与服务, 2024, 42(8): 334-340. doi: 10.12206/j.issn.2097-2024.202303023
[20]	冯志惠, 邓仪卿, 叶冰, 安培, 张宏, 张海军. 雀梅藤石油醚提取物诱导三阴性乳腺癌细胞凋亡的实验研究 . 药学实践与服务, 2024, 42(6): 253-259. doi: 10.12206/j.issn.2097-2024.202311055

点击查看大图

计量

文章访问数: 5238
HTML全文浏览量: 314
PDF下载量: 1028
被引次数: 0

姓名
邮箱
手机号码
标题
留言内容
验证码

留言板

核糖体蛋白S3a在肿瘤细胞增殖分化和凋亡调控作用的研究概况

doi: 10.3969/j.issn.1006-0111.2012.03.003

Progress on the role of Ribosomal Protein S3a in regulation of proliferation, differentiation and apoptosis in tumor cells

计量

核糖体蛋白S3a在肿瘤细胞增殖分化和凋亡调控作用的研究概况

doi: 10.3969/j.issn.1006-0111.2012.03.003

第二军医大学药学院生化药学教研室,上海 200433

English Abstract

Progress on the role of Ribosomal Protein S3a in regulation of proliferation, differentiation and apoptosis in tumor cells

Department of Biochemical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433 China

全文HTML

目录

留言板

核糖体蛋白S3a在肿瘤细胞增殖分化和凋亡调控作用的研究概况

doi: 10.3969/j.issn.1006-0111.2012.03.003

Progress on the role of Ribosomal Protein S3a in regulation of proliferation, differentiation and apoptosis in tumor cells

计量

出版历程

核糖体蛋白S3a在肿瘤细胞增殖分化和凋亡调控作用的研究概况

doi: 10.3969/j.issn.1006-0111.2012.03.003

第二军医大学药学院生化药学教研室,上海 200433

English Abstract

Progress on the role of Ribosomal Protein S3a in regulation of proliferation, differentiation and apoptosis in tumor cells

Department of Biochemical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433 China

全文HTML

目录