呋喃西林溶液制备方法改进及稳定性比较
Improvement of preparation and the stability of furacillin solution
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摘要: 目的: 改进呋喃西林溶液制备方法,观察其稳定性。 方法: 对原处方的制备工艺加以改进,并通过留样观察对呋喃西林溶液进行定性分析和紫外分光光度法定量测定。 结果: 改进法配制的呋喃西林溶液稳定性好,4个月内未析出沉淀,含量合格;原法配制的呋喃西林溶液2个月后析出红棕色沉淀,含量不合格。 结论: 改进后的配制方法操作简单,溶液的稳定性提高,贮存期延长。Abstract: Objective To improve the preparation method for furacillin solution and observe the stability of the solution. Methods The original preparation technics was modified.The furacillin solution was qualitatively analyzed by observation and quantitatively determined by UV spectrophotometry. Results The furacillin solution prepared in new method was proved to be stable in quality,without separating sediments in 4 months.However,sediment of furacillin solution prepared in old method was observed,color of the solution became deeper and content was out of quality 2 months later. Conclusion Improved method is convenient and feasible,which could increase the stability and ensure the safety and efficacy of furacillin solution in clinical use.
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Key words:
- furacillin solution /
- preparation method /
- stability
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