血清丙戊酸、卡马西平血清样品的稳定性考察
Study on stability of valproic acid and carbamazepine concentrations in serum samples
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摘要: 目的: 考察丙戊酸、卡马西平血清样品保存条件对血清药物浓度的影响。 方法: 取癫痫患者血清样品,在取血当天、冰箱冷藏(5℃±1℃)保存7 d、常温(23℃±2℃)保存7 d与14 d后,用荧光偏振免疫法测定血清丙戊酸、卡马西平浓度并进行比较,考察其稳定性。 结果: 室温保存7 d、14 d或冷藏保存7 d的血样测定结果与取血当天测定结果比较无统计学差异。 结论: 丙戊酸、卡马西平血清样品在室温下可稳定保存14d。Abstract: Objective: To investigate the effects on serum drug concentrations of valproic acid and carbamazepine with different storage requirements of serum sample. Methods: Methods The serum samples from epileptic patients were stored at normal temperature(23 ℃±2 ℃)for 7 days and 14 days or in refrigerator(5 ℃±1 ℃) for 7 days.Then these samples were determined by FPIA and the results were compared with the new ones. Results: Compared with the new samples,the samples which were stored for 7 or 14 days were no significant differences. Conclusion: Serum samples of valproic acid and carbamazepine can be stored stably at normal temperature for 14 days.
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Key words:
- valproic acid /
- carbamazepine /
- serum drug concentration
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