不同绕水平轴旋转刺激方式诱发的大鼠晕动病反应

阳盛洪; 粟志远; 王强; 黄矛

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不同绕水平轴旋转刺激方式诱发的大鼠晕动病反应

阳盛洪, 粟志远, 王强, 黄矛

文章导航 > 药学实践与服务 > 2007 > (2): 78-79,87

阳盛洪, 粟志远, 王强, 黄矛. 不同绕水平轴旋转刺激方式诱发的大鼠晕动病反应[J]. 药学实践与服务, 2007, (2): 78-79,87.

引用本文:

阳盛洪, 粟志远, 王强, 黄矛. 不同绕水平轴旋转刺激方式诱发的大鼠晕动病反应[J]. 药学实践与服务, 2007, (2): 78-79,87.

YANG Sheng-hong, LI Zhi-yuan, WANG qiang, HUANG Mao. Study on the choice of stimulation to motion sickness in rats[J]. Journal of Pharmaceutical Practice and Service, 2007, (2): 78-79,87.

Citation:

YANG Sheng-hong, LI Zhi-yuan, WANG qiang, HUANG Mao. Study on the choice of stimulation to motion sickness in rats[J]. Journal of Pharmaceutical Practice and Service, 2007, (2): 78-79,87.

不同绕水平轴旋转刺激方式诱发的大鼠晕动病反应

第二军医大学新药评价中心,,上海200433

基金项目: 军队科研基金(01-L035)

Study on the choice of stimulation to motion sickness in rats

Center for Evaluation of Drug Safety,Second Military Medical University,Shanghai 200433,China

摘要: 目的: 比较4种刺激模式对大鼠晕动病的诱发效应。 方法: 40只雄性SD大鼠随机分成旋转方式1组、旋转方式2组、旋转方式3组、旋转方式4组和对照组。以旋转刺激前后各2d食高岭土总量的差值为评价指标。旋转方式1组和旋转方式2组分别采用交替加减速顺时针垂直旋转(18°/s²角加速度加速,最大速度达120°/s,再以48°/s²速度减速至0),刺激60 min和90 min;旋转方式3组采用交替加减速顺时针垂直旋转(48°/s²角加速度加速,最大速度达120°/s,再以48°/s²速度减速至0),刺激时间60 min;旋转方式4组采用匀速顺时针垂直旋转(120°/s),刺激时间60 min。 结果: 在4种刺激模式中,旋转方式1组、旋转方式2组和旋转方式3组大鼠2d高岭土摄取总量差值显著高于对照组(旋转方式2组P＜0．01,旋转方式1组和旋转方式3组P＜0．05),其中,旋转方式2组大鼠2d高岭土摄取总量差值显著高于旋转方式1组和旋转方式3组(P＜0．01)。 结论: 旋转方式1组、旋转方式2纽和旋转方式3组均能诱发大鼠晕动病的发生,其中旋转方式2组诱发效果较好。
- 晕动病 /
- 刺激模式 /
- 高岭土 /
- 异食癖 /
- 动物模型 /
- 大鼠
Abstract: Objective: To compare the effect of four stimulator to induce motion sickness in rats. Methods: 40 male SD rats were di-vided into four groups randomly.The induced motion sickness was determined by the assay of kaolin intake 2 days before and 2 days after rotational stimulation.GroupⅠwere stimulated in a rotator with ahernately variable speed for 1h,which were rotated clockwise around a horizontal axis at an angular acceleration of 18°/s² until the angular velocity reached 120°/s.Then the device was decelerated at an angu-lar acceleration of 48°/s² until rotation stopped.GroupⅡwere treated identically except that they were rotated for 1.5h.GroupⅢwere stimulated with alternately variable speed for 1h,which rotated clockwise around a horizontal axis at an angular acceleration of 48°/s² un-til the angular velocity reached 120°/s.Then the device was decelerated at the same rate until rotation stopped.GroupⅣwere rotated at 120°/s clockwise around a horizontal axis. Results: Among the four groups,the difference of kaolin intake before and after rotation of groupⅠ,groupⅡand groupⅢwere significantly more than that of control group(groupⅡP＜0.01,groupⅠand groupⅢP＜0.05).The difference of kaolin intake before and after rotation of groupⅡwas more than others(P＜0.01). Conclusion: The rotational stimulation of groupⅠ,groupⅡand groupⅢcan induce motion sickness in rats,and groupⅡwere the most effective.
- motion sickness /
- stimulus modehty /
- kaolin /
- Pica /
- animal model /
- rats

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不同绕水平轴旋转刺激方式诱发的大鼠晕动病反应

第二军医大学新药评价中心,,上海200433

基金项目: 军队科研基金(01-L035)

收稿日期: 2006-12-25

关键词:

晕动病 /

刺激模式 /

高岭土 /

异食癖 /

动物模型 /

大鼠

摘要: 目的: 比较4种刺激模式对大鼠晕动病的诱发效应。 方法: 40只雄性SD大鼠随机分成旋转方式1组、旋转方式2组、旋转方式3组、旋转方式4组和对照组。以旋转刺激前后各2d食高岭土总量的差值为评价指标。旋转方式1组和旋转方式2组分别采用交替加减速顺时针垂直旋转(18°/s²角加速度加速,最大速度达120°/s,再以48°/s²速度减速至0),刺激60 min和90 min;旋转方式3组采用交替加减速顺时针垂直旋转(48°/s²角加速度加速,最大速度达120°/s,再以48°/s²速度减速至0),刺激时间60 min;旋转方式4组采用匀速顺时针垂直旋转(120°/s),刺激时间60 min。 结果: 在4种刺激模式中,旋转方式1组、旋转方式2组和旋转方式3组大鼠2d高岭土摄取总量差值显著高于对照组(旋转方式2组P＜0．01,旋转方式1组和旋转方式3组P＜0．05),其中,旋转方式2组大鼠2d高岭土摄取总量差值显著高于旋转方式1组和旋转方式3组(P＜0．01)。 结论: 旋转方式1组、旋转方式2纽和旋转方式3组均能诱发大鼠晕动病的发生,其中旋转方式2组诱发效果较好。

English Abstract

Study on the choice of stimulation to motion sickness in rats

Center for Evaluation of Drug Safety,Second Military Medical University,Shanghai 200433,China

Received Date: 2006-12-25

Keywords:

Abstract: Objective: To compare the effect of four stimulator to induce motion sickness in rats. Methods: 40 male SD rats were di-vided into four groups randomly.The induced motion sickness was determined by the assay of kaolin intake 2 days before and 2 days after rotational stimulation.GroupⅠwere stimulated in a rotator with ahernately variable speed for 1h,which were rotated clockwise around a horizontal axis at an angular acceleration of 18°/s² until the angular velocity reached 120°/s.Then the device was decelerated at an angu-lar acceleration of 48°/s² until rotation stopped.GroupⅡwere treated identically except that they were rotated for 1.5h.GroupⅢwere stimulated with alternately variable speed for 1h,which rotated clockwise around a horizontal axis at an angular acceleration of 48°/s² un-til the angular velocity reached 120°/s.Then the device was decelerated at the same rate until rotation stopped.GroupⅣwere rotated at 120°/s clockwise around a horizontal axis. Results: Among the four groups,the difference of kaolin intake before and after rotation of groupⅠ,groupⅡand groupⅢwere significantly more than that of control group(groupⅡP＜0.01,groupⅠand groupⅢP＜0.05).The difference of kaolin intake before and after rotation of groupⅡwas more than others(P＜0.01). Conclusion: The rotational stimulation of groupⅠ,groupⅡand groupⅢcan induce motion sickness in rats,and groupⅡwere the most effective.

阳盛洪, 粟志远, 王强, 黄矛. 不同绕水平轴旋转刺激方式诱发的大鼠晕动病反应[J]. 药学实践与服务, 2007, (2): 78-79,87.

引用本文:

阳盛洪, 粟志远, 王强, 黄矛. 不同绕水平轴旋转刺激方式诱发的大鼠晕动病反应[J]. 药学实践与服务, 2007, (2): 78-79,87.

YANG Sheng-hong, LI Zhi-yuan, WANG qiang, HUANG Mao. Study on the choice of stimulation to motion sickness in rats[J]. Journal of Pharmaceutical Practice and Service, 2007, (2): 78-79,87.

Citation:

YANG Sheng-hong, LI Zhi-yuan, WANG qiang, HUANG Mao. Study on the choice of stimulation to motion sickness in rats[J]. Journal of Pharmaceutical Practice and Service, 2007, (2): 78-79,87.